Calvin observes that the righteous need not fear that their cause will be overlooked if they suffer patiently and bear injuries with moderation. Here God comes as Abel’s avenger and takes up the cause of his faithful martyr to vindicate him, when in obedience to his Lord Abel has suffered particularly for his faith.
Every man is truly his brother’s keeper and also his neighbour’s keeper. The summary of the second table of the law is expressed in these terms: ‘Thou shalt love thy neighbour as thyself.’ For Cain to keep his brother in the sense of caring for him and in showing concern for his welfare was a wholly natural thing to do.
God is omnipotent and omniscient, and you cannot conceal anything from him. Unbelief and rebellion lead somehow to the blanking out of all awareness of God as God. It is so with all of us before we are converted. It never occurs to us that God actually sees us and sees into our minds, and knows our thoughts and our motives. Even if we half believe in him as an entity of some kind who exists, we sin as though he is unseeing. So it's not surprising to see Cain without the slightest idea that God knows exactly what he's done.