Job had to bear the great indignity of having been a man for whom there was universal respect, and now falling to the level of someone who even the lowest in society openly mocked and insulted. His name which had been honoured had now become a byword for a hypocrite: one whom God has made an example of.
We must be prepared to put up with even this, for no less a thing happened to our Saviour. He was insulted by men though he was the Lord of glory, and guided by the attitude of the Jewish leaders, the common people regarded him as one who was being punished for his own sin on the cross. ‘He is despised and rejected of men; a man of sorrows, and acquainted with grief: and we hid as it were our faces from him; he was despised, and we esteemed him not’ (Isaiah 53:3). Therefore if Satan is allowed to present us to the world as its offscouring, and as nothing, it is no surprise. This will do us no permanent harm, for God will glorify us as the sons of God when the full light of day comes.
The KJV treats the second part of verse 6 as Job looking back to a better past life, and uses the word tabret, meaning timbrel or tambourine. But most understand this to be in line with the first part of the verse, and to mean that men spat in his presence as a show of contempt.