One of the tragic things about being lost, being unconverted, is that it is full of self-hurt. We hurt ourselves only.
But it is so with lost people. You apply this spiritually. Before we come to the Lord, we are harming ourselves non-stop. We increase in cynicism, we go further from God, we become more subject to our lusts, we suffer all kinds of disappointments and ultimately judgement from God. It is self-harm through unbelief; it is very sad.