This plague goes to the heart of the enemy’s operation, the throne of the beast. This throne was given to him by the dragon, Satan (13:2).
The ultimate punishment is when the gospel is taken from a nation and wisdom is removed and false religion takes over. the kingdom of this world will be allowed to fall victim to its own values of darkness. We see society getting worse and worse, and yet its counsellors tell us that the solution is more of the same: keep going in the same direction. No one will acknowledge the consequences of the permissive society.